No one can predict the future, but this set probably won't give you great returns. D-O 75278 has been on sale fairly constantly at 20% off, was clearanced at multiple retailers with deep discounts, and has been a slow mover off LEGO Store Shelves. While I suspect this set will be done by the end of the year, it's not exactly a strong performer - And if you are dipping your toes in the LEGO investing waters, you probably could do much better with your set choice - Unless you are getting this at an extremely deep discount.
So in short, yes I believe this set will be retiring soon, but in long - It might not be the best investing target. Check out the "What Sets to Invest in Thread" for some deeper dives and more information.