There's a whole bunch they can do with this line. They could in theory make more UCS type playsets or structures based off disney characters. While I would suspect this set to be out for 5 to 6 years easily, it will eventually retire, as well. But, I think this, along with the Disney minifigures series are the first in a long long line of these things. They'll tap this market to death, just like they did and are doing with Star Wars, and Marvel.
Personally, i'm not so sold on the disney minifigures being as big of an investment as people are chirping on here. Maybe initially, but over time it wont be, after the 50th mickey mouse is released in a set, or the 20th alice in wonderland playset is released with yet another alice. Just watch. Those sets are coming, and it's obvious.
Now if they will just release a star wars minifigures series so we can finally add Zuckuss, and 4Lom to the collection, i'd be a happy cat.